Here, you can find a list of Preprints, Publications, and Patents by the Mirica Group. After reading through our publication list, take a look at our Research Overview and our commonly used Techniques/Instruments. If you have questions about our work, please feel free to Contact Us!
Preprints & Submitted Manuscripts
126. Bae, D. Y.; Ruhs, N. P.; Mirica, L. M. Aerobic Base-free C–H Bond Activation at a Pd Center in Aqueous Conditions. ChemRxiv 2025. Preprint: https://doi.org/10.26434/chemrxiv-2025-zxdm5.
125. Sayed, T. E.; Terpstra, K.; Whetter, J.; Xu, K.; Zhu, L.; Chakrabarti, S.; Marlin, A.; Wessel, A.; Majumdar, S.; Sutton, B.; Boros, E.; Mirica, L. M. Pyridinophane Ligands: An Attractive Chelator Platform for Mn-Based Imaging Agents. ChemRxiv, 2025. Preprint: https://doi.org/10.26434/chemrxiv-2025-snpm4.
Publications
124. Burke, J. H.; Johnsen, M.; Wallick, R. F.; Gnewkow, R.; Bae, D. Y.; Ravi, A. J.; Rossi, T. C.; Eckert, S.; Fondell, M.; van Spronsen, M. A.; Schaller, R. D.; Alfaro, V. S.; Lee, S. J.; Gee, L. B.; Mirica, L. M.; van der Veen, R. M.; Vura-Weis, J. How Does Metal Spin State Affect Electronic Communication in Mixed-Valence Dimers? Insights from Ultrafast Near-Infrared and Soft X-ray Transient Absorption Spectroscopy. Inorg. Chem. 2026, 65, 4, 2136–2149. https://doi.org/10.1021/acs.inorgchem.5c03543
123. Chakrabarti, S.; Chae, J. B.; Knecht, K. A.; Cedron, N. D.; Woods, T. J.; Mirica, L. M. Catalytically competent nickel(I)–isocyanide compounds for cross-coupling reactions. Nat Catal, 2026. https://doi.org/10.1038/s41929-025-01473-9
News release (Illinois News Bureau)
122. Holm, A. R.; Wallick, R. F.; Vura-Weis, J.; Mirica, L. M. Illuminating the Role of Alcohol Substrate in Nickel Photoredox Catalysis via Ground State and Transient Absorption Spectroscopy. ACS Catal. 2026, 16, 2, 1522–1532. https://doi.org/10.1021/acscatal.5c07700.
Featured by Hepatochem as a Favorite Photochemistry Paper of 2025
121. Chakrabarti, S.;‡ Leung, J. J.;‡ Cedron, N.; Mirica, L. M. Intermolecular C(sp2)–H Activation in a Palladium(II) Complex Supported by a p-Me2N-Thiapyridinophane Ligand. Organometallics. 2026, 45, 3, 225–230. https://doi.org/10.1021/acs.organomet.5c00336 ‡Co-first authors
Featured on the front cover: Organometallics 2026, 45, 3, 225.
120. Boros, E.; Comba, P.; Engle, J. W.; Harriswangler, C.; Lapi, S. E.; Lewis, J. S.; Mastroianni, S.; Mirica, L. M.; Platas-Iglesias, C.; Ramogida, C. F.; Tripier, R.; Tosato, M. Chemical Tools to Characterize the Coordination Chemistry of Radionuclides for Radiopharmaceutical Applications. Chem. Rev. 2025, 125, 24, 12030–12068. https://doi.org/10.1021/acs.chemrev.5c00641
119. Chakrabarti, S.;‡ Banerjee, S.;‡ Mirica, L. M. Capturing the Hybrid Palladium(I)-Radical Pair Relevant to Photoexcited Palladium Catalysis. J. Am. Chem. Soc. 2025, 147, 45, 41882–41896. https://doi.org/10.1021/jacs.5c14709. ‡Co-first authors
News release (Illinois News Bureau) & Featured structure (CCDC)
118. Terpstra, K.; Gutiérrez, C.; Gui, K.; Mirica, L. M. Donepezil and Memantine Derivatives for Dual-Function and Prodrug Applications in Alzheimer’s Disease. ACS Chem. Neurosci. 2025, 16, 18, 3591–3602. https://doi.org/10.1021/acschemneuro.5c00493. PDF
117. Bouley, B. S.;‡ Bae, D. Y.;‡ Zhou, W.; Griego, L.; Mirica, L. M. Oxidative Addition of Aryl Bromides at Palladium(I) to form Palladium(III) Complexes. Angew. Chem. Int. Ed. 2025, e202514101. https://doi.org/10.1002/anie.202514101. PDF ‡Co-first authors
116. Bouley, B. S.;‡ Bae, D. Y.;‡ Chakrabarti, S.;‡ Rosen, M.; Kennedy, R. D.; Mirica, L. M. Insights into the mechanism of active catalyst generation for the PdII(acac)2/PPh3 system in the context of telomerization of 1,3-butadiene. Chem. Sci. 2025, 16, 15486-15498.https://doi.org/10.1039/D5SC02171E. PDF ‡Co-first authors
115. Gutiérrez, C.; Sun, L.; Huang, Y.; Gui, K.; Terpstra, K.; Mirica, L. M. N-Alkylamino Stilbene Compounds as Amyloid β Inhibitors for Alzheimer’s Disease Research. Molecules 2025, 30, 2471. https://doi.org/10.3390/molecules30112471. PDF
114. Nath, S., Griego, L. & Mirica, L. M. The mechanism of acetyl-CoA synthase through the lens of a nickel model system. Nat. Commun. 16, 5177 (2025). https://doi.org/10.1038/s41467-025-60163-z. PDF
Highlighted in Nature Catalysis: Peterson, E. Nat Catal. 2025, 8, 508.
News release (Illinois News Bureau)
113. Westawker, L. P.; Bouley, B. S.; Vura-Weis, J.; Mirica, L. M.Photochemistry of Ni(II) tolyl chlorides supported by bidentate ligand frameworks. J. Am. Chem. Soc. 2025, 147, 20, 17315–17329. https://doi.org/10.1021/jacs.5c03770. PDF
112. Banerjee, S.;‡ Chakrabarti, S.;‡ Bouley, B. S.; Wahlmeier, A. J.; Mirica, L. M. Mononuclear palladium(I) and palladium(III) coordination compounds. Coordination Chemistry Reviews 2025, 535, 216605. https://doi.org/10.1016/j.ccr.2025.216605. PDF ‡Co-first authors
111. Leung, J. J.;‡ Bae, D. Y.;‡ Moshood, Y.;‡ Mirica, L. M. C–C and C–O Bond Formation Reactivity of Nickel Complexes Supported by the Pyridinophane MeN3C Ligand. Dalton Trans. 2025, 54, 5286-5292. https://doi.org/10.1039/D5DT00135H. PDF ‡Co-first authors
110. Yerbulekova, A.;‡ Moshood, Y.;‡ Griego, L.; Shafaat, H. S.; Mirica, L. M. Spectroscopic and Computational Interrogation of a High-Valent Nickel-Dialkyl Complex Indicates Electronic Structure Asymmetry Drives C−C Bond Formation Reactivity. J. Am. Chem. Soc. 2025, 147, 9, 7317–7324. https://doi.org/10.1021/jacs.4c14104. PDF ‡Co-first authors
109. Rodriguez Carrero, R. J.; Lloyd, C. T.; Borkar, J.; Nath, S.; Mirica, L. M.; Nair, S.; Booker, S. J.; Metcalf W. Genetic and biochemical characterization of a radical SAM enzyme required for post-translational glutamine methylation of methyl-coenzyme M reductase. mBio. 2025, 16, 2, e03546-24. https://doi.org/10.1128/mbio.03546-24. PDF
108. Wu, Y.; Torabi, S.-F.; Lake, R.; Yang, Z.; Hong, S.; Yu, Z.; Mirica, L. M.; Fonken, L.; Lu, Y. Deciphering Iron Redox Changes in Alzheimer’s Disease using DNAzyme Sensors that can Simultaneously Monitor Fe2+ and Fe3+. Alzheimer’s Dement. 2025, 20, 1, e088440. https://doi.org/10.1002/alz.088440. PDF
107. Rana, M.; Terpstra, K.; Gutierrez, C.; Xu, K.; Arya, H.; Bhatt T. K.; Mirica, L. M.; Kumar Sharma, A. K. Evaluation of Anti-Alzheimer’s Potential of Azo-Stilbene-Thioflavin-T derived Multifunctional Molecules: Synthesis, Metal and Aβ Species Binding and Cholinesterase Activity. Chem. Eur. J. 2024, 31, e202402748. https://doi.org/10.1002/chem.202402748. PDF
106. Chakrabarti, S.; Mirica, L. M. Quantifying Zinc and Manganese Reduction Potentials in Organic Solvents. Chem. 2024, 10, 11, 3273-3275. https://doi.org/10.1016/j.chempr.2024.10.015. PDF
105. Chae, J. B.; Holm, A. R.; Mirica, L. M. Radical control for enantioselective Csp3–Csp3 cross-coupling. Nat. Catal. 2024, 7, 857–859. https://doi.org/10.1038/s41929-024-01208-2. PDF
104. Terpstra, K.; Huang, Y.; Na, H.; Sun, L.; Gutierrez, C.; Yu, Z.; Mirica, L. M. 2-Phenylbenzothiazolyl Iridium Complexes as Inhibitors and Probes of Amyloid β Aggregation. Dalton Trans. 2024, 53, 14258. https://doi.org/10.1039/D4DT01691B. PDF
103. Burke, J. H.; Bae, D. Y.; Wallick, R. F.; Dykstra, C. P.; Rossi, T. C.; Smith, L. E.; Leahy, C. A.; Schaller, R. D.; Mirica, L. M.; Vura-Weis, J.; van der Veen, R. M. High-Spin State of a Ferrocene Electron Donor Revealed by Optical and X-Ray Transient Absorption Spectroscopy. J. Am. Chem. Soc. 2024, 146 (31), 21651–21663. https://doi.org/10.1021/jacs.4c05646. PDF
102. Na, H.; Wessel, A. J.; Kim, S.-T.; Baik, M.-H.; Mirica, L. M. C(sp³)–H Bond Activation Mediated by a Pd(II) Complex under Mild Conditions. Inorg. Chem. Front. 2024, 11 (14), 4415–4423. https://doi.org/10.1039/D4QI01017E. PDF
101. Wallick, R. F.; Chakrabarti, S.; Burke, J. H.; Gnewkow, R.; Chae, J. B.; Rossi, T. C.; Mantouvalou, I.; Kanngießer, B.; Fondell, M.; Eckert, S.; Dykstra, C.; Smith, L. E.; Vura-Weis, J.; Mirica, L. M.; van der Veen, R. M. Excited-State Identification of a Nickel-Bipyridine Photocatalyst by Time-Resolved X-Ray Absorption Spectroscopy. J. Phys. Chem. Lett. 2024, 15 (18), 4976–4982. https://doi.org/10.1021/acs.jpclett.4c00226. PDF
100. Bouley, B. S.; Garvey, I. J.; Na, H.; Chae, J. B.; Mirica, L. M. Anagostic Axial Interactions Inhibit Cross-Coupling Catalytic Activity in Square Planar Pyridinophane Nickel Complexes. ChemCatChem 2024, 16 (5), e202301677. https://doi.org/10.1002/cctc.202301677. PDF
99. Griego, L.;‡ Chae, J. B.;‡ Mirica, L. M. A Bulky 1,4,7-Triazacyclononane and Acetonitrile, a Goldilocks System for Probing the Role of Ni(III) and Ni(I) Centers in Cross-Coupling Catalysis. Chem. 2024, 10 (3), 867–881. https://doi.org/10.1016/j.chempr.2023.11.008. PDF ‡Co-first authors
Highlighted in Chem: Lloret-Fillol, J. Chem. 2024, 10, (3) 753-755.
News release (Illinois News Bureau)
98. Yu, Z.; Blade, G.; Bouley, B. S.; Dobrucki, I. T.; Dobrucki, L. W.; Mirica, L. M. Coordination Chemistry of Sulfur-Containing Bifunctional Chelators: Toward in Vivo Stabilization of 64Cu PET Imaging Agents for Alzheimer’s Disease. Inorg. Chem. 2023, 62 (50), 20820–20833. https://doi.org/10.1021/acs.inorgchem.3c02929. PDF
97. Westawker, L. P.; Khusnutdinova, J. R.; Wallick, R. F.; Mirica, L. M. Palladium K-edge XAS studies on Controlled Ligand Systems. Inorg. Chem. 2023. 62, 51, 21128–21137. https://doi.org/10.1021/acs.inorgchem.3c03032. PDF
96. Hu, C. H.; Chae, J. B.; Mirica, L. M. Improved Synthesis of Chiral 1,4,7-Triazacyclononane Derivatives and Their Application in Ni-catalyzed C(sp³)–C(sp³) Kumada Cross-coupling. Helv. Chim. Acta. 2024, 107, e202300170. https://doi.org/10.1002/hlca.202300170. PDF
Scott Denmark 70th Birthday Special Collection
95. Blade, G.; Wessel, A. J.; Terpstra K.; Mirica, L. M. Pentadentate and Hexadentate Pyridinophane Ligands Support Reversible Cu(II)/Cu(I) Redox Couples. Inorganics. 2023, 11, 11, 446. https://doi.org/10.3390/inorganics11110446. PDF
Special issue on the bioinorganic chemistry of copper.
94. Chakrabarti, S; Woods, T. J.; Mirica, L. M. Insights into the Mechanism of CO2 Electroreduction by Molecular Palladium-Pyridinophane Complexes. Inorg. Chem. 2023, 62, 41, 16801–16809. https://doi.org/10.1021/acs.inorgchem.3c02236. PDF
93. Yu, Z.; Moshood, Y.; Wozniak, M. K.; Patel, S.; Terpstra, K.; Llano, D. A.; Dobrucki, L. W.; Mirica, L. M. Amphiphilic Molecules Exhibiting Zwitterionic Excited-State Intramolecular Proton Transfer and Near-Infrared Emission for the Detection of Amyloid β Aggregates in Alzheimer’s Disease. Chem. Eur. J. 2023, 29, e202302408. https://doi.org/10.1002/chem.202302408. PDF
92. DiMucci, I. M.; Titus, C. J.; Nordlund, D.; Bour, J. R.; Chong, E.; Grigas, D. P.; Hu, C.-H.; Kosobokov, M. D.; Martin, C. D.; Mirica, L. M.; Nebra, N.; Vicic, D. A.; Yorks, L. L.; Yruegas, S.; MacMillan, S. N.; Shearer, J.; Lancaster, K. M. Scrutinizing Formally Ni(IV) Centers through the Lenses of Core Spectroscopy, Molecular Orbital Theory, and Valence Bond Theory. Chem. Sci. 2023, 14, 6915-6929, https://doi.org/10.1039/D3SC02001K. PDF
91. Hu, C. -H., Kim, S. -T., Baik, M. -H., Mirica, L. M. Nickel–Carbon Bond Oxygenation with Green Oxidants via High-Valent Nickel Species. J. Am. Chem. Soc. 2023, 145, 20, 11161–11172, https://doi.org/10.1021/jacs.3c01012. PDF
90. Torabi, S.-F.; Wu, Y.; Lake, R. J.; Hong, S.; Yu, Z.; Wu, P.; Yang, Z.; Ihms, H.; Nelson, N.; Guo, W.; Pawel, G. T.; Van Stappen, J.; Shao, X.; Mirica, L. M.; Lu, Y. Simultaneous Fe2+/3+ imaging shows Fe3+ over Fe2+ enrichment in Alzheimer’s disease mouse brain, Sci. Adv. 2023, 9, 16, 1-14, eade7622, https://doi.org/10.1126/sciadv.ade7622. PDF
News Release (UT Austin, College of Natural Sciences)
89. Bouley, B. S.; Tang, F.; Bae, D. Y.; Mirica, L. M. C–H Bond Activation via Concerted Metalation-Deprotonation at a Palladium(III) Center. Chem. Sci. 2023, 14, 3800-3808, https://doi.org/10.1039/D3SC00034F. PDF
88. Chakrabarti, S.; Sinha, S.; Tran, G. N.; Na, H.; Mirica, L. M. Characterization of Paramagnetic States in an Organometallic Nickel Hydrogen Evolution Electrocatalyst, Nat. Commun. 2023, 14, 905. https://doi.org/10.1038/s41467-023-36609-7. PDF
News release (Illinois News Bureau)
87. Terpstra, K.; Wang, Y.; Huynh, T. T.; Bandara, N.; Cho, H.-J.; Rogers, B. E.; Mirica, L. M. Divalent 2-(4-Hydroxyphenyl)benzothiazole Bifunctional Chelators for 64Cu PET Imaging in Alzheimer’s Disease, Inorg. Chem., 2022, 61, 20326–20336, https://doi.org/10.1021/acs.inorgchem.2c02740. PDF
86. Yu, Z.; Guo, W.; Patel, S.; Cho, H.-J.; Sun, L.; Mirica, L. M. Amphiphilic Stilbene Derivatives Attenuate the Neurotoxicity of Soluble Aβ42 Oligomers by Controlling Their Interactions with Cell Membranes. Chem. Sci, 2022, 13, 12818-12830, https://doi.org/10.1039/D2SC02654F. PDF
85. Tran, G. N.; Bouley, B. S.; Mirica, L. M. Isolation and Catalytic Reactivity of Mononuclear Palladium(I) Complexes. J. Am. Chem. Soc., 2022, 144, 20008-20015, https://doi.org/10.1021/jacs.2c08765. PDF
84. Wang, Y.-C.; Rath, N. P., Mirica, L. M. Allylic Amination of Pd(II)-Allyl Complexes via High-Valent Pd Intermediates. Organometallics, 2022, 41, 2067–2076, https://doi.org/10.1021/acs.organomet.2c00215. PDF
83. Griego, L.; Woods, T. J.; Mirica, L. M. A Five-Coordinate Ni(I) Complex Supported by 1,4,7-Triisopropyl-1,4,7-triazacyclononane. Chem. Comm., 2022, 58, 7360-7363, https://doi.org/10.1039/d2cc02516g. PDF
Featured on the front cover: Chem. Commun., 2022, 58, 7327.
82. Iyer, R. R.; Renteria, C. A.; Yang, L.; Sorrells, J. E.; Park, J.; Sun, L.; Yu, Z.; Huang, Y.; Marjanovic, M.; Mirica, L. M.; Boppart, S. A. Tracking the binding of multi-functional fluorescent tags for Alzheimer’s disease using quantitative multiphoton microscopy. J. Biophotonics, 2022, 15, e202200105, https://doi.org/10.1002/jbio.202200105. PDF
81. Huynh, T. T.; Wang, Y.; Terpstra, K.; Cho, H.-J.; Mirica, L. M.; Rogers, B. E. 68Ga-Labeled Benzothiazole Derivatives for Imaging Aβ Plaques in Cerebral Amyloid Angiopathy. ACS Omega, 2022, 7, 20339-20346, https://doi.org/10.1021/acsomega.2c02369. PDF
80. Rana, M.; Cho, H.-J.; Arya, H.; Bhatt, T.; Bhar, K.; Bhatt, S.; Mirica, L. M.; Sharma, A. K. Novel Azo-Stilbene and Pyridine-Amine Hybrid Multifunctional Molecules to Target Metal Mediated Neurotoxicity and Amyloid-β Aggregation in Alzheimer’s disease. Inorg. Chem, 2022, 61, 10294-10309, https://doi.org/10.1021/acs.inorgchem.2c00502. PDF
79. Huang, Y.; Sun, L.; Mirica, L. M. Turn-on Fluorescent Sensors for Cu-rich Amyloid β Peptide Aggregates. Sens. Diagn., 2022, 1, 709-713, https://doi.org/10.1039/D2SD00028H. PDF
78. Huang, Y.; Huynh, T. T.; Sun, L.; Hu, C.-H.; Wang, Y.-C.; Rogers, B. E.; Mirica, L. M. Neutral Ligands as Potential 64Cu Chelators for Positron Emission Tomography Imaging Applications in Alzheimer’s Disease. Inorg. Chem., 2022, 61, 4778−4787, https://doi.org/10.1021/acs.inorgchem.2c00621. PDF
77. Wang, Y.; Huynh, T. T.; Bandara, N.; Cho, H.-J.; Rogers, B. E.; Mirica, L. M. 2-(4-Hydroxyphenyl)benzothiazole Dicarboxylate Ester TACN Chelators for 64Cu PET imaging in Alzheimer’s Disease. Dalton Trans. 2022, 51, 1216-1224, https://doi.org/10.1039/D1DT02767K. PDF
76. Na, H.; Mirica, L. M. Deciphering the mechanism of the Ni-photocatalyzed C‒O cross-coupling reaction using a tridentate pyridinophane ligand. Nat. Commun., 2022, 13, 1313, https://doi.org/10.1038/s41467-022-28948-8. PDF
Behind the paper from Nature Portfolio Chemistry Community
75. Magallon, C.; Griego, L.; Hu, C. H.; Company, A; Ribas, X.; Mirica, L. M. Organometallic Ni(II), Ni(III), and Ni(IV) Complexes Relevant to Carbon-Carbon and Carbon-Oxygen Bond Formation Reactions. Inorg. Chem. Front., 2022, 9, 1016-1022, https://doi.org/10.1039/D1QI01486B. PDF
74. Sinha, S.; Tran, G. N.; Na, H.; Mirica, L. M. Electrocatalytic H2 Evolution Promoted by a Bioinspired (N2S2)Ni(II) Complex. Chem. Comm., 2022, 58, 1143–1146, https://doi.org/10.1039/D1CC05139C. PDF
73. Wang, Y.; Huynh, T. T.; Cho, H.-J.; Wang, Y.-C.; Rogers, B. E.; Mirica, L. M. Amyloid β-Binding Bifunctional Chelators with Favorable Lipophilicity for 64Cu Positron Emission Tomography Imaging in Alzheimer’s Disease. Inorg. Chem. 2021, 60, 12610–12620, https://doi.org/10.1021/acs.inorgchem.1c02079. PDF
72. Gardner, S. H.; Brady, C. J.; Keeton, C.; Yadav, A. K.; Mallojjala, S. C.; Lucero, M. Y.; Su, S.; Yu, Z.; Hirschi, J. S.; Mirica, L. M.; Chan, J. A General Approach to Convert Hemicyanine Dyes into Highly Optimized Photoacoustic Scaffolds for Analyte Sensing. Angew. Chem. Int. Ed. 2021, 60, 18860-18865, https://doi.org/10.1002/anie.202105905. PDF
71. Na, H., Watson, M. B., Tang, F., Rath, N. P., Mirica, L. M. Photoreductive Chlorine Elimination from a Ni(III)Cl2 Complex Supported by a Tetradentate Pyridinophane Ligand. Chem. Comm., 2021, 57, 7264-7267, https://doi.org/10.1039/D1CC02114A. PDF
70. Sun, L.; Cho, H.-J.; Sen, S.; Arango, A. S.; Bandara, N.; Huang, Y.; Huynh, T. T.; Rogers, B. E.; Tajkhorshid, E.; Mirica, L. M. Amphiphilic Distyrylbenzene Derivatives as Potential Therapeutic and Imaging Agents for the Soluble Amyloid-β Oligomers in Alzheimer’s Disease. J. Am. Chem. Soc. 2021, 143, 10462-10476, https://doi.org/10.1021/jacs.1c05470. PDF
69. Sinha, S.; Mirica, L. M. Electrocatalytic O2 Reduction by an Organometallic Pd(III) Complex via a Binuclear Pd(III) Intermediate. ACS Catal. 2021, 11, 5202-5211, https://doi.org/10.1021/acscatal.0c05726. PDF
68. Fuchigami, K.; Watson, M. B.; Tran, G. N.; Rath, N. P.; Mirica, L. M. Synthesis and Reactivity of (N2P2)Ni Complexes Stabilized by a Diphosphonite Pyridinophane Ligand. Organometallics 2021, 40,2283–2289, https://doi.org/10.1021/acs.organomet.1c00003. PDF
67. Heberer, N.; Hu, C.-H.; Mirica, L. M. High-Valent Ni Coordination Compounds. In Comprehensive Coordination Chemistry III, Constable, E. C.; Parkin, G.; Que Jr, L., Eds. Elsevier: Oxford, 2021; pp 348, https://doi.org/10.1016/B978-0-08-102688-5.00104-5. PDF
66. Chakrabarti, S.; Sinha, S.; Mirica, L. M. High-Valent Pd Coordination Compounds. In Comprehensive Coordination Chemistry III, Constable, E. C.; Parkin, G.; Que Jr, L., Eds. Elsevier: Oxford, 2021; pp 375, https://doi.org/10.1016/B978-0-08-102688-5.00105-7. PDF
65. Berry, J. F.; Mirica, L. M. Transition Metal Groups 9–11: An Introduction. In Comprehensive Coordination Chemistry III, Constable, E. C.; Parkin, G.; Que Jr, L., Eds. Elsevier: Oxford, 2021; pp 1, https://doi.org/10.1016/B978-0-08-102688-5.00119-7. PDF
64. Cho, H.-J.; Huynh, S.; Rogers, B. E.; Mirica, L. M. Successful Design of a Multivalent Bifunctional Chelator for Diagnostic 64Cu PET Imaging in Alzheimer’s Disease, Proc. Natl. Acad. Sci. U.S.A., 2020, 117, 30928-30933, https://doi.org/10.1073/pnas.2014058117. PDF
Highlighted in Synfacts: Trauner, D.; Ko, T., Synfacts 2021, 17, 0337.
63. Luo, J.; Tran, G. N.; Rath, N. P.; Mirica, L. M. Detection and Characterization of Mononuclear Pd(I) Complexes Supported by N2S2 and N4 Tetradentate Ligands, Inorg. Chem. 2020, 59, 15659–15669, https://doi.org/10.1021/acs.inorgchem.0c01938. PDF
62. Sun L.; Sharma, A. K.; Han, B. H.; Mirica, L. M. Amentoflavone: A Bifunctional Metal Chelator that Controls the Formation of Neurotoxic Soluble Aβ42 Oligomers, ACS Chem. Neurosci. 2020, 11, 2741–2752, https://doi.org/10.1021/acschemneuro.0c00376, PMID: 32786307, NIHMSID 1646840. PDF
61. Huang, Y.; Cho, H.-J.; Bandara, N.; Sun, L.; Tran, D.; Rogers, B. E.; Mirica, L. M. Metal-Chelating Benzothiazole Multifunctional Compounds for the Modulation and 64Cu PET Imaging of Aβ Aggregation, Chem. Sci. 2020, 11, 7789-7799, https://doi.org/10.1039/d0sc02641g. PDF
Featured on the back cover. Chem. Sci., 2020,11, 8041-8041
60. Schultz, J. W.; Rath, N. P.; Mirica, L. M. Improved Oxidative C–C Bond Formation Reactivity of High-Valent Pd Complexes Supported by a Pseudo-Tridentate Ligand. Inorg. Chem. 2020, 59, 11782-11792, https://doi.org/10.1021/acs.inorgchem.0c01763. PDF
59. Cho, H.-J.; Sharma, A. K.; Zhang, Y.; Gross, M. L.; Mirica, L. M. A Multifunctional Chemical Agent as an Attenuator of Amyloid and Tau Burden and Neuroinflammation in Alzheimer’s Disease, ACS Chem. Neurosci. 2020, 11, 1471–1481, https://doi.org/10.1021/acschemneuro.0c00114, PMID 32310630, NIHMSID 1646839; Altmetric: https://acs.altmetric.com/details/80230580. PDF
58. Mirica, L. M.; Smith, S. M.; Griego, L. Organometallic Chemistry of High-Valent Ni(III) and Ni(IV) Complexes, invited book chapter in Nickel Catalysis in Organic Synthesis: Methods and Reactions, Ed. S. Ogoshi, Wiley-VCH, 2019, https://doi.org/10.1002/9783527813827.ch10. PDF
57. Smith, S. M.; Planas, O.; Gómez, L.; Rath, N. P.; Ribas, X.; Mirica, L. M. Aerobic C–C and C–O Bond Formation Reactions Mediated by High-Valent Nickel Species, Chem. Sci., 2019, 10, 10366–10372, https://doi.org/10.1039/c9sc03758f. PDF
56. Smith, S. M.; Rath, N. P.; Mirica, L. M. Axial Donor Effects on Oxidatively Induced Ethane Formation from Nickel–Dimethyl Complexes, Organometallics, 2019, 38, 3602-3609, https://doi.org/10.1021/acs.organomet.9b00438. PDF
55. Ruhs, N. P.; Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M. Mononuclear Organometallic Pd(II), Pd(III), and Pd(IV) Complexes Stabilized by a Pyridinophane Ligand with a C-Donor Group, Organometallics, 2019, 38, 3834-3843, https://doi.org/10.1021/acs.organomet.9b00505. PDF
54. Tang, F; Park, S.; Rath, N. P.; Mirica, L. M. Electronic versus Steric Effects of Pyridinophane Ligands in Pd(III) Complexes, Dalton Trans., 2018, 47, 1151-1158, https://doi.org/10.1039/c7dt04366j. PDF
53. Rana, M.; Cho, H.-J.; Roy, T. K.; Mirica, L. M.; Sharma, A. K. Azo-dyes based small bifunctional molecules for metal chelation and controlling amyloid formation, Inorg. Chim. Acta, 2018, 471, 419-429, https://doi.org/10.1016/j.ica.2017.11.029, PMID: 30344337, PMCID: PMC6191838. PDF
52. Wessel, A. J.; Schultz, J. W.; Tang, F; Duan, H.; Mirica, L. M. Improved Synthesis of Symmetrically & Asymmetrically N-Substituted Pyridinophane Derivatives, Org. & Biomol. Chem., 2017, 15, 9923 – 9931, https://doi.org/10.1039/c7ob02508d. PDF
51. Sharma, A. K.; Schultz, J. W.; Prior, J. T.; Rath, N. P.; Mirica, L. M. The Coordination Chemistry of Bifunctional Chemical Agents Designed for Applications in 64Cu PET Imaging for Alzheimer’s Disease, Inorg. Chem., 2017, 56, 13801-13814, https://doi.org/10.1021/acs.inorgchem.7b01883, PMID: 29112419, PMCID: PMC5698879. PDF
50. Bandara, N.; Sharma, A. K.; Krieger, S.; Schultz, J. W.; Han, B. H.; Rogers, B. E.; Mirica, L. M. Evaluation of 64Cu-Based Radiopharmaceuticals that Target Aβ Peptide Aggregates as Diagnostic Tools for Alzheimer’s Disease, J. Am. Chem. Soc., 2017, 139, 12550-12558, https://doi.org/10.1021/jacs.7b05937, PMID: 28823165, PMCID: PMC5677763. PDF
49. Fuchigami, K.; Rath, N. P.; Mirica, L. M. Mononuclear Rhodium(II) and Iridium(II) Complexes Supported by Tetradentate Pyridinophane Ligands, Inorg. Chem., 2017, 56, 9404-9408, https://doi.org/10.1021/acs.inorgchem.7b01619. PDF
48. Cascella, B.; Lee, S. G.; Singh, S.; Jez, J. M.; Mirica, L. M. The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A, Chem. Comm. 2017, 53, 2174-2177; https://doi.org/10.1039/c6cc09882g. PDF
47. Mendez, D. L.; Babbitt, S. E.; King, J. D.; D’Alessandro, J.; Watson, M. B.; Blankenship, R. E.; Mirica, L. M.; Kranz, R. G. Engineered holocytochrome c synthases that biosynthesize new cytochromes c, Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 2235-2240, https://doi.org/10.1073/pnas.1615929114. PDF
46. Waston, M. B.; Rath, N. P.; Mirica, L. M. Oxidative C–C Bond Formation Reactivity of Organometallic Ni(II), Ni(III), and Ni(IV) Complexes, J. Am. Chem. Soc., 2017, 139, 35-38; https://doi.org/10.1021/jacs.6b10303. PDF
45. Schultz, J. W.; Fuchigami. K.; Zheng, B.; Rath, N. P.; Mirica, L. M. Isolated Organometallic Nickel(III) and Nickel(IV) Complexes Relevant to Carbon-Carbon Bond Formation Reactions, J. Am. Chem. Soc., 2016, 138, 12928-12934; https://doi.org/10.1021/jacs.6b06862. PDF
44. Zhou, W.; Watson, M. B.; Zheng, S.; Rath, N. P.; Mirica, L. M. Ligand effects on the properties of Ni(III) complexes: aerobically-induced aromatic cyanation at room temperature, Dalton Trans., 2016, 137, 15886-15893; https://doi.org/10.1039/c6dt02185a. PDF
43. Orf, G. S.; Saer, R. G.; Niedzwiedzki, D. M.; Zhang, H.; McIntosh, C. L.; Schultz, J. W.; Mirica, L. M.; Blankenship, R. E. Evidence for a cysteine-mediated mechanism of excitation energy regulation in a photosynthetic antenna complex, Proc. Natl. Acad. Sci. U. S. A., 2016, 113, E4486-E4493, https://doi.org/10.1073/pnas.1603330113. PDF
42. Pedrick, E. A.; Schultz, J. W.; Wu, G.; Mirica, L. M.; Hayton, T. W. Perturbation of the O–U–O Angle in Uranyl by Coordination to a 12-Membered Macrocycle, Inorg. Chem., 2016, 55, 5693-5701; https://doi.org/10.1021/acs.inorgchem.6b00799. PDF
41. Zhou, W.; Zheng, S.; Schultz, J. W.; Rath, N. P.; Mirica, L. M. Aromatic Cyanoalkylation through Double C–H Activation Mediated by Ni(III), J. Am. Chem. Soc., 2016, 138, 5777-5780; https://doi.org/10.1021/jacs.6b02405. PDF
40. Zhou, W.; Rath, N. P.; Mirica, L. M. Oxidatively-induced aromatic cyanation mediated by Ni(III), Dalton Trans., 2016, 137, 8693-8695; https://doi.org/10.1039/c6dt00064a. PDF
39. Zhou, W.; Schultz, J. W.; Rath, N. P.; Mirica, L. M. Aromatic Methoxylation and Hydroxylation by Organometallic High-Valent Nickel Complexes, J. Am. Chem. Soc., 2015, 137, 7604-7607; https://doi.org/10.1021/ jacs.5b04082. PDF
38. Tang, F.; Rath, N. P.; Mirica, L. M. Stable Bis(trifluoromethyl)Nickel(III) Complexes, Chem. Comm., 2015, 51, 3113-3116; https://doi.org/10.1039/c4cc09594d. PDF
37. Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M. The Conformational Flexibility of the Tetradentate Ligand tBuN4 is Essential for the Stabilization of (tBuN4)PdIII Complexes, Inorg. Chem., 2014, 53, 13112-13129, https://doi.org/10.1021/ic5023054. PDF
36. Sharma, A. K.; Kim, J.; Prior, J. T.; Hawco, N. J.; Rath, N. P.; Kim, J.; Mirica, L. M. Small Bifunctional Chelators that Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity, Inorg. Chem., 2014, 53, 11367-11376, https://doi.org/10.1021/ic500926c. PDF
35. Zheng, B.; Tang, F.; Luo, J.; Schultz, J. W.; Rath, N. P.; Mirica, L. M. Organometallic Nickel(III) Complexes Relevant to Cross-Coupling and Carbon-Heteroatom Bond Formation Reactions, J. Am. Chem. Soc., 2014, 136, 6499-6504; https://doi.org/10.1021/ja5024749. PDF
34. Qu, F.; Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M. Dioxygen Activation by an Organometallic Pd(II) Precursor: Formation of a Pd(IV)–OH Complex and Its C–O Bond Formation Reactivity, Chem. Comm., 2014, 50, 3036-3039; https://doi.org/10.1039/c3cc49387c. PDF
33. Sharma, A. K.; Pavlova, S. T.; Kim, J.; Kim, J.; Mirica, L. M. The Effect of Cu2+ and Zn2+ on the Ab42 Peptide Aggregation and Cellular Toxicity, Metallomics, 2013, 5, 1519-1526; https://doi.org/10.1039/c3mt00161j. PDF
32. Zhang, Y.; Rempel, D. L.; Zhang, J.; Sharma, A. K.; Mirica, L. M.; Gross M. L. Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation, Proc. Natl. Acad. Sci. U. S. A., 2013, 110, 14604-14609; https://doi.org/10.1073/pnas.1309175110. PDF
31. Khusnutdinova, J. R.; Mirica, L. M. Organometallic Pd(III) Complexes in C–C and C–Heteroatom Bond Formation Reactions, invited book chapter in C–H Activation and Functionalization, Transition Metal Mediation, Ed. Ribas, X., Royal Society of Chemistry, 2013; https://doi.org/10.1039/9781849737166-00122. PDF
30. Luo, J.; Rath, N. P.; Mirica, L. M. Oxidative Reactivity of (N2S2)PdRX Complexes (R = Me, Cl; X = Me, Cl, Br): Involvement of Palladium(III) and Palladium(IV) Intermediate, Organometallics, 2013, 32, 3343-3353; https://doi.org/10.1021/om400286j. PDF
29. Khusnutdinova, J. R.; Luo, J.; Rath, N. P.; Mirica, L. M. Late First Row Transition Metal Complexes of a Tetradentate Pyridinophane Ligand: Electronic Properties and Reactivity Implications, Inorg. Chem., 2013, 52,3920-3932, https://doi.org/10.1021/ic400260z. PDF
28. Mirica, L. M.; Khusnutdinova, J. R., Structure and Electronic Properties of Pd(III) Complexes, Coord. Chem. Rev., 2013, 257, 299-314. https://doi.org/10.1016/j.ccr.2012.04.030. PDF
27. Cascella, B.; Mirica, L. M. Kinetic Analysis of Iron-Dependent Histone Demethylases: a-Ketoglutarate Substrate Inhibition and Potential Relevance to the Regulation of Histone Demethylation in Cancer Cells, Biochemistry, 2012, 51, 8699-8701, https://doi.org/10.1021/bi3012466. PDF
26. Tang, F.; Qu, F.; Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M. Structural and Reactivity Comparison of Analogous Organometallic Pd(III) and Pd(IV) Complexes, Dalton Trans., 2012, 41, 14046-14050, https://doi.org/10.1039/C2DT32127K. PDF
25. Tang, F.; Zhang, Y.; Rath, N. P.; Mirica, L. M. Detection of Pd(III) and Pd(IV) Intermediates during the Aerobic Oxidative C–C Bond Formation from a Pd(II) Dimethyl Complex, Organometallics, 2012, 31, 6690-6696. https://doi.org/10.1021/om300752w. PDF
24. Khusnutdinova, J. R.; Qu, F.; Zhang, Y.; Rath, N. P.; Mirica, L. M. Formation of the Pd(IV) Complex [(Me3tacn)PdIVMe3]+ through Aerobic Oxidation of (Me3tacn)PdIIMe2 (Me3tacn = N,N’,N’’-trimethyl-1,4,7-triazacyclononane), Organometallics, 2012, 31, 4627-4630,https://doi.org/10.1021/om300426r. PDF
Featured on the front cover: Organometallics, 2012, 31, 4627.
23. Evangelio, E.; Rath, N. P.; Mirica, L. M. Cycloaddition Reactivity Studies of First Row Transition Metal-Azide Complexes and Alkynes: An Inorganic Click Reaction for Metalloenzyme Inhibitor Synthesis, Dalton Trans., 2012, 41, 8010-8021, https://doi.org/10.1039/c2dt30145h. Invited contribution for the “New Talent Americas” issue. PDF
22. Sharma, A. K.; Pavlova, S. T.; Kim, J.; Finkelstein, D.; Hawco, N. J.; Rath, N. P.; Kim, J.; Mirica, L. M. Bifunctional Metal-Binding Compounds for Controlling the Metal-Mediated Aggregation of the Aβ42 Peptide, J. Am. Chem. Soc., 2012, 134, 6625-6636, https://doi.org/10.1021/ja210588m. PDF
21. Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M. The Aerobic Oxidation of a Pd(II) Dimethyl Complex Leads to Selective Ethane Elimination from a Pd(III) Intermediate, J. Am. Chem. Soc., 2012, 134, 2414-2422, https://doi.org/10.1021/ja210841f. PDF
20. Luo, J.; Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M. Unsupported d8-d8 Interactions in Cationic PdII and PtII Complexes: Evidence for a Significant Metal-Metal Bonding Character, Chem. Comm., 2012, 48, 1532-1534, https://doi.org/10.1039/c1cc15420f. Invited contribution for the “Emerging Investigators” issue. PDF
19. Luo, J.; Rath, N. P.; Mirica, L. M. Dinuclear Co(II)Co(III) Mixed-Valence and Co(III)Co(III) Complexes with N- and O- Donor Ligands: Characterization and Water Oxidation Studies, Inorg. Chem., 2011, 50,6152-6157, https://doi.org/10.1021/ic201031s. PDF
18. Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M. Dinuclear Pd(III) Complexes with a Single Unsupported Bridging Halide Ligand: Reversible Formation from Mononuclear Pd(II) or Pd(IV) Precursors, Angew. Chem. Int.Ed., 2011, 50, 5532-5536, https://doi.org/10.1002/anie.201100928. PDF
17. Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M. Stable Mononuclear Organometallic Pd(III) Complexes and Their C–C Bond Formation Reactivity, J. Am. Chem. Soc., 2010, 132, 7303-7305; https://doi.org/10.1021/ja103001g. PDF
Featured as “News of the Week” in Chem. & Eng. News, 2010, 88, 21, 9.
Publications from Postdoctoral & Ph.D. Studies
16. Verma, P.; Weir, J.; Mirica, L. M.; Stack, T. D. P. Tale of a Twist: Magnetic and Optical Switching in Copper(II) Semiquinone Complexes, Inorg. Chem., 2011, 50,9816-9825; https://doi.org/10.1021/ic200958g, PMID: 2169132. PDF
15. Op’t Holt, B. T.; Vance, M. A.; Mirica, L. M.; Heppner, D. E.; Stack, T. D. P., Solomon E. I. Reaction Coordinate of a Functional Model of Tyrosinase: Spectroscopic and Computational Characterization, J. Am. Chem. Soc., 2009, 131, 6421-6438; https://doi.org/10.1021/ja807898h. PDF
14. Humphreys, K. J.; Mirica, L. M.; Wang Y.; Klinman, J. P. Galactose Oxidase as a Model for Reactivity at a Copper Superoxide Center, J. Am. Chem. Soc., 2009, 131, 4657-4663, https://doi.org/10.1021/ja807963e. PDF
13. Mirica, L. M.; McCusker, K. P.; Munos, J. W.; Liu, H. W.; Klinman, J. P. Probing the Nature of Reactive Fe/O2 Intermediates in Non-Heme Iron Enzymes through 18O Kinetic Isotope Effects, J. Am. Chem. Soc., 2008, 130, 8122-8123. https://doi.org/10.1021/ja800265s. PDF
12. Mirica, L. M.; Klinman, J. P. The Nature of O2 Activation by the Ethylene-Forming Enzyme ACC Oxidase, Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 1814-1819, https://doi.org/10.1073/pnas.0711626105. PDF
11. Welford, R. W. D.; Lam, A.; Mirica, L. M.; Klinman, J. P. Partial Conversion of Hansenula polymorpha Amine Oxidase into a ‘Plant’ Amine Oxidase: Implications for Copper Chemistry and Mechanism, Biochemistry, 2007, 46, 10817-10827, https://doi.org/10.1021/bi700943r. PDF
10. Thrower, J. T.; Mirica, L. M.; McCusker, K. P.; Klinman, J. P. Mechanistic Investigations of 1-Aminocylcyclopropane 1-Carboxylic Acid Oxidase with Alternate Cyclic and Acyclic Substrates, Biochemistry, 2006, 45, 13108-13117, https://doi.org/10.1021/bi061097q. PDF
9. Mirica, L. M.; Rudd, D. J.; Vance, M.; Solomon, E. I.; Hedman, B.; Hodgson, K. O.; Stack, T. D. P. A m–h2:h2-Peroxodicopper(II) Complex with a Secondary Diamine Ligand: A Functional Model of Tyrosinase, J. Am. Chem. Soc., 2006, 128, 2654-2665, https://doi.org/10.1021/ja056740v. PDF
8. Cole, A. P.; Mahadevan, V.; Mirica, L. M.; Ottenwaelder, X.; Stack, T. D. P. Bis(m-oxo)dicopper(III) Complexes of a Homologous Series of Simple Peralkylated 1,2-Diamines: Steric Modulation of Structure, Stability, and Reactivity, Inorg. Chem., 2005, 44, 7345-7364, https://doi.org/10.1021/ic050331i. PDF
7. Yoon, J.; Mirica, L. M.; Stack, T. D. P.; Solomon, E. I. Variable-Temperature Variable-Field Magnetic Circular Dichroism Studies of Tris-Hydroxy and m3-Oxo Bridged Trinuclear Cu(II) Complexes: Geometric and Electronic Structures of the Native Intermediate of Multicopper Oxidases, J. Am. Chem. Soc., 2005, 127, 13680-13693, https://doi.org/10.1021/ja0525152. PDF
6. Mirica, L. M.; Vance, M.; Rudd, D. J.; Hedman, B.; Hodgson, K. O.; Solomon, E. I.; Stack, T. D. P. Tyrosinase Reactivity in a Model Complex: An Alternative Hydroxylation Mechanism, Science, 2005, 308, 1890-1892l; https://doi.org/10.1126/science.1112081. PDF
Featured as a perspective in Science, 2005, 308, 1876-1877.
Featured as a science concentrate in Chem. & Eng. News, 2005, 83, 26, 38.
5. Mirica, L. M.; Stack, T. D. P. A Tris(m-hydroxy)tricopper(II) Complex as a Model of the Native Intermediate in Laccase and Its Relationship to a Binuclear Analogue, Inorg. Chem., 2005, 44, 2131-2133, https://doi.org/10.1021/ic048182b. PDF
4. Pratt, R. C.; Mirica, L. M.; Stack, T. D. P. Snapshots of a Metamorphosing Cu(II) Ground State in a Galactose Oxidase-Inspired Complex, Inorg. Chem., 2004, 43, 8030-8039, https://doi.org/10.1021/ic048904z. PDF
3. Yoon, J.; Mirica, L. M.; Stack, T. D. P.; Solomon, E. I. Spectroscopic Demonstration of a Large Antisymmetric Exchange Contribution to the Spin-Frustrated Ground State of a D3 Symmetric Hydroxy-Bridged Trinuclear Cu(II) Complex: Ground-to-Excited State Superexchange Pathways, J. Am. Chem. Soc., 2004, 126, 12586-12595, https://doi.org/10.1021/ja046380w. PDF
2. Mirica, L. M.; Ottenwaelder, X.; Stack, T. D. P. Structure and Spectroscopy of Copper–Dioxygen Complexes, Chem. Rev., 2004, 104, 1013-1046, https://doi.org/10.1021/cr020632z. PDF
1. Mirica, L. M.; Vance, M.; Rudd, D. J.; Hedman, B.; Hodgson, K. O.; Solomon, E. I.; Stack, T. D. P. A Stabilized m–h2:h2-Peroxodicopper(II) Complex with a Secondary Diamine Ligand and Its Tyrosinase-like Reactivity, J. Am. Chem. Soc. 2002, 124, 9332-9333, https://doi.org/10.1021/ja026905p. PDF
Patents
3. Mirica, L. M.; Yu, Z. Amphiphilic Compounds for Attenuating Neurotoxicity of Amyloid-beta Oligomers and Diagnostic Methods. U.S. Patent provisional application no. 63/389,270, filing date: July 14, 2022.
2. Mirica, L. M.; Na, H., Tridentate Macrocyclic Compounds. U.S. Patent No. 11827653, issued November 28, 2023. PDF
1. Mirica, L. M.; Sharma, A. K.; Schultz, J. W. Metal-Binding Bifunctional Compounds as Diagnostic Agents for Alzheimer’s Disease. U.S. Patent No. 9422286, issued August 23, 2016. PDF